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KMID : 0043319790020020085
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Archives of Pharmacal Research
1979 Volume.2 No. 2 p.85 ~ p.88
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Interfacial and Free Energy Effects in Aqueous Amide Cosolvents
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Lee CH
Lindstrom RE
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Abstract
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Data on the solubility of p-hydroxybenzoate in amide-water cosolvent system and surface tension of the binary amide-water cosolvents are analyzed in terms of the possible mechanism for cosolvency. The results of the study suggest that strong partitioning of the alkylated amides to the ester surface, thus reducing the hydrophobic interface within the system, may account for much of the cosolvency phenomena observed in these systems.
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